2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143436
    TNIK-IN-4
    		Inhibitor
    TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116.
    TNIK-IN-4
  • HY-108717A
    Recombinant Proteinase K (DNase & RNase free, animal free)
    Recombinant Proteinase K (DNase & RNase free, animal free) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection. This product is of molecular biology grade, free of animal-derived ingredients, and is recombinantly purified from yeast.
    Recombinant Proteinase K (DNase & RNase free, animal free)
  • HY-B1624C
    Debrisoquin hydrobromide
    		Inhibitor
    Debrisoquine (Ro 5-3307/1) hydrobromide is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquine hydrobromide can be used for antiviral research.
    Debrisoquin hydrobromide
  • HY-N4331
    Rivulariapeptolides 1185
    		Inhibitor
    Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively.
    Rivulariapeptolides 1185
  • HY-123542
    ONO-3403
    		Inhibitor
    ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors.
    ONO-3403
  • HY-149310
    Dim16
    		Inhibitor
    Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells.
    Dim16
  • HY-P2978
    Alpha 1 Antichymotrypsin, Human Plasma
    		Inhibitor
    Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor. Alpha 1 Antichymotrypsin, Human Plasma appears in the amyloid lesions of Alzheimer's disease. Alpha 1 Antichymotrypsin, Human Plasma can be used in Alzheimer's disease research.
    Alpha 1 Antichymotrypsin, Human Plasma
  • HY-P2101
    Micropeptin 478A
    		Inhibitor
    Micropeptin 478A is a plasmin inhibitor from cyanobacteria with an IC50 of 0.1 μg/mL. Micropeptin 478A can be used to study bleeding disorders.
    Micropeptin 478A
  • HY-19472A
    RWJ-58643 hydrochloride
    RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.
    RWJ-58643 hydrochloride
  • HY-P3863
    Pancreastatin (swine)
    		Inhibitor
    Pancreastatin (swine) is a 49-residue peptide which strongly inhibits glucose-induced insulin release. Pancreastatin (swine) can be isolated and characterized from porcine pancreas.
    Pancreastatin (swine)
  • HY-19472
    RWJ-58643
    		Inhibitor
    RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells.
    RWJ-58643
  • HY-134445
    N-Benzoyl-L-tyrosine p-nitroanilide
    N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate.
    N-Benzoyl-L-tyrosine p-nitroanilide
  • HY-P4464
    Ala-Phe-Pro-pNA
    Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity.
    Ala-Phe-Pro-pNA
  • HY-137281
    HMB-Val-Ser-Leu-VE
    		Inhibitor
    HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM.
    HMB-Val-Ser-Leu-VE
  • HY-119467
    MDK0734
    MDK0734 is a selective inhibitor that inhibits feline hepsin B endopeptidase and exopeptidase activities. MDK0734 demonstrated efficacy in a cell-based in vitro tumor invasion model, significantly attenuating the invasive ability of MCF-10A neoT cells. MDK0734 provides new potential inhibitors for the development of clinically useful compounds targeting the deleterious effects of feline hepsin B in cancer progression.
    MDK0734
  • HY-114080B
    Patamostat hydrochloride
    		Inhibitor
    Patamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis.
    Patamostat hydrochloride
  • HY-P4477
    Suc-AAPR-pNA
    Suc-AAPR-pNA is a substrate of trypsin acyl-enzymes. Suc-AAPR-pNA can be used to test trypsin acyl-enzymes activity.
    Suc-AAPR-pNA
  • HY-P5280
    Ac-KQL-AMC
    Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome.
    Ac-KQL-AMC
  • HY-N3997
    Nostosin G
    		Inhibitor
    Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC50 value of 0.1 μM.
    Nostosin G
  • HY-176518
    ssPalmE-P4-C2
    ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research.
    ssPalmE-P4-C2
Cat. No. Product Name / Synonyms Application Reactivity